Magnetic liposome

Product Name

Magnetic liposome

Product Overview

Magnetic liposomes are generally composite nanocarriers obtained by encapsulating iron oxide (Fe3O4) in the aqueous phase of lipid bilayers or embedding it in lipid bilayer membranes. They combine the advantages of liposomes as a biological carrier with the magnetic response characteristics of magnetic nanoparticles, and belong to multifunctional biological nanocarriers, which are widely used in biomedical research.

Technical Parameter

Concentration:5 mg/mL(Calculated based on the amount of phospholipids added) 1 mg/mL(Calculated based on the feed rate of magnetic particles) Solvent : Water

Diameter :<10 nm,200 nm,500 nm

Appearance <10 nm:Yellow brown solution 200 nm: Brown solution 500 nm: Brown black solution

Product Features

1) Magnetic targeting ability: Under the guidance of an external magnetic field, magnetic liposomes can be enriched to the target site, reducing the distribution of drugs throughout the body, increasing local drug concentration in the lesion, and reducing systemic toxic side effects; It is a physical active targeting method beyond passive targeting. 2) Integrated diagnosis and treatment: Due to its excellent magnetic material as a contrast agent for magnetic resonance imaging, it can achieve targeted therapy while conducting real-time MRI imaging tracking. This "integrated diagnosis and treatment" capability provides the possibility for personalized medicine and real-time evaluation of therapeutic efficacy. 3) Excellent biocompatibility: Liposomes themselves are composed of phospholipid bilayers, which have good biocompatibility and biodegradability. Wrapping magnetic materials inside also effectively solves the problems of easy aggregation and poor stability of bare magnetic nanoparticles.

Application Fields

1) Magnetic targeted chemotherapy: Magnetic fields guide the enrichment of magnetic liposomes at the tumor site, encapsulating chemotherapy drugs such as doxorubicin and paclitaxel to reduce systemic toxicity in the heart, bone marrow, and other systems. 2) Magnetic resonance contrast agent: Compared to pure iron oxide nanoparticles, the liposome shell improves particle dispersion and prolongs in vivo circulation time. 3) Gene delivery: encapsulating plasmid DNA, siRNA, mRNA; Magnetic field assisted cell transfection efficiency, also known as magnetic transfection. Compared to conventional lipid transfection, an external magnetic field can quickly pull the carrier onto the cell surface, improve transfection efficiency, and reduce reagent usage; Used for in vitro cell transfection and in vivo local gene therapy.

Related Information

Sealed, avoid light, and keep at 4°C. Do not freeze. Expiry date: 1 months. Please e-mail for the detailed characterization data. E-mail:sales@xfnano.com