Polycaprolactone

Product Name Polycaprolactone Product Overview Polycaprolactone (PCL) microspheres are medical-grade flexible degradable polymer microsphere materials with excellent biocompatibility, ultra-long controllable degradation cycle and outstanding mechanical flexibility, serving as core high-end scientific research consumables in regenerative medicine, long-term drug sustained release and tissue engineering. This series of scientific research-grade monodisperse micron-scale PCL microspheres covers a particle size gradient range from 10 μm to 50 μm, with a uniform solid content of 2.5% and a single bottle volume of 10 ml. Prepared by high-precision emulsion polymerization and precise classification technology, the products feature full sphericity, uniform particle size, no irregular particles and excellent batch stability. Different from fast-degrading polyester materials such as PLA and PGA, PCL degrades gently and uniformly without acidic accumulation or local inflammatory stimulation, with an in-vivo degradation cycle of 18~24 months, which can accurately match the rhythm of human tissue regeneration and repair. With excellent original dispersion and stable structure, the product supports diversified surface functional modification, combining flexible support and long-term metabolic characteristics. It is widely applied in cutting-edge scientific research scenarios such as biomedical long-term drug delivery, soft tissue repair, medical aesthetic material R&D, environmental degradation simulation and polymer material modification. Technical Parameter Dispersion Solvent Sterile Deionized Water Solid Content 2.5% Surface Modification Unmodified; Support customized modification of various functional groups such as amino, carboxyl and biotin Surface Charge Original weak negative charge with stable properties, accurately adjustable by surface modification Milky white uniform suspension dispersion Storage Condition 2~8°C Shelf Life 12 months(Under standardized unopened refrigerated storage conditions) Storage Condition 2~8°C Store in a cool, dark place in a sealed container. Do not freeze and thaw, expose to high temperatures, or leave at room temperature for extended periods. Shelf Life 12个月(Under standardized unopened refrigerated storage conditions) Product Features •Ultra-long Uniform Controllable Degradation Without Acid Residue Stimulation: Compared with fast-degrading polyester materials such as PLA and PGA, PCL microspheres have a degradation cycle of 18~24 months with uniform and mild degradation process. It does not produce a large amount of acidic deposits, effectively avoiding local inflammation and tissue irritation, perfectly matching the regeneration and repair cycle of human soft tissues with extremely high biological safety. •Medical-grade High Biocompatibility for High-end Biological Scenarios: The product is prepared from high-purity medical-grade PCL raw materials, with non-toxicity, non-sensitization and non-cell irritation. It passes standard biosafety evaluation and will not cause immune rejection reactions, which can be directly applied to high-end scientific research fields such as in-vivo experiments, tissue engineering and long-term drug delivery. •Excellent Micron-scale Monodispersity and Strong Experimental Stability: Adopting precise classification and purification technology, the gradient particle sizes of 10~50μm are uniform and regular with full sphericity and no agglomeration. With PDI ≤ 0.3 and excellent batch consistency, it effectively ensures accurate and repeatable experimental data for drug loading, tissue culture and material modification. Excellent Flexible Mechanical Properties with Both Support and Adaptability: PCL material has good flexibility and structural stability, combining mechanical support and tissue adhesion. It can •not only provide structural support as a long-term scaffold, but also adapt to the dynamic repair scenarios of soft tissues, with far better adaptability than hard degradable microspheres. •Customizable Functions to Meet Diverse Scientific Research Needs: The original microspheres have stable performance, and various surface functional groups such as amino, carboxyl and biotin can be customized as required to realize targeted drug loading, biomolecular coupling and specific adsorption, accurately matching differentiated scientific research experimental needs. •Standardized Mass Production with Significant Cost Performance Advantages: All series adopt unified mass production and transparent pricing. The 2.5% high solid content ratio provides sufficient materials. Compared with similar medical-grade degradable microspheres, it has stable quality and outstanding cost performance, suitable for batch scientific research experiments and new material R&D. Application Fields •Long-term Sustained-release Drug Delivery: Relying on ultra-long controllable degradation cycle and excellent biocompatibility, it can efficiently load proteins, polypeptides, hormones, anti-inflammatory and anti-tumor drugs to achieve months-level long-term uniform sustained release, stabilize in-vivo drug concentration, reduce administration frequency and lower toxic and side effects, serving as a core carrier material for the R&D of long-term sustained-release preparations. •Tissue Engineering and Soft Tissue Regeneration: It can be used as a 3D cell culture carrier and soft tissue repair scaffold for research scenarios such as skin repair, subcutaneous tissue regeneration and soft tissue filling reconstruction. The flexible material fits the mechanical properties of human tissues and synchronously matches the rhythm of tissue growth and degradation. •Medical Aesthetic Regenerative Material R&D: It is applied to the scientific research of medical aesthetic materials such as long-term contour filling, soft tissue capacity repair and collagen regeneration stimulation. With the characteristics of mild degradation, no residue and low irritation, it is a core research substrate for regenerative medical aesthetic filling materials. •Biomedical Material Modification: Used for the modified filling of degradable medical coatings, flexible composite biological materials and implantable consumables to improve the flexibility, biological adaptability and long-term stability of materials and optimize the comprehensive performance of medical materials. •Environmental Degradable Material Research: It can be used in scientific experiments such as degradation mechanism of polyester degradable materials, environmental adaptability, microplastic alternative materials and ecotoxicology, providing data support for the R&D of green degradable polymer materials. •Colloid and Bio-interface Research: Monodisperse micron-scale PCL microspheres can be used in basic research such as bio-interface adsorption, colloid suspension stability and cell-material interaction mechanism, with excellent experimental repeatability and data stability. User Guide 1. All products of this series are scientific research-grade consumables, only for laboratory scientific research, not for medical injection or industrial end products, and are prohibited from direct human clinical injection and treatment. 2. The products need to be sealed and refrigerated at 2~8°C away from light. Freezing, high-temperature exposure, long-term storage at room temperature and repeated freeze-thaw are strictly prohibited. It is recommended to use up within 1 month after opening to prevent microsphere sedimentation, agglomeration and dispersion failure. 3. All series support customized modification of surface functional groups. The quotation and customization cycle vary with different modification processes. Please consult customer service in advance to confirm specific parameters and schemes before ordering. 4. The parameters in this specification are general standard values. Minor physical deviations between batches are within the industry allowable error range and will not affect conventional scientific research experiments. 5. PCL material has long-term degradable characteristics. Long-term exposure to high temperature, strong acid, alkali and strong organic solvent environments should be avoided to prevent premature degradation and structural damage of microspheres and ensure experimental validity.