{"product_id":"recombinant-human-il-1-beta-protein-his-tag","title":"Recombinant Human IL-1 beta Protein (His-tag)","description":"\u003cp\u003eDESCRIPTION Gene Name Synonym IL-1 beta, IL1B, IL1F2, IL-1β Species Human Accession P01584 Source HEK293 cells SPECIFICATIONS Amino acid sequence Ala117-Ser269 is expressed with a 10×His tag at the N terminus Molecular Weight 18.8 kDa Purity \u0026gt;95.0% as determined by SDS-PAGE Endotoxin \u0026lt;5 EU·mg-1 Formulation Lyophilized from sterile PBS, pH 7.4. Normally 5%-8% trehalose and mannitol are added as protectants before lyophilization. Reconstitution Dissolved in sterile water, it is recommended to add 0.1% HSA or BSA for long-term preservation. STORAGE Stability and Storage 12 months from date of receipt at -20°C to -70°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for almost 6 months (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage. BACKGROUND Interleukin-1 beta (IL1 beta or IL1B) also known as catabolin, is a member of the interleukin 1 cytokine family. In clinical, it has been reported that Interleukin (IL)-1 may influence Th1 \/ Th2 immune responsiveness and has been implicated in the establishment of a successful pregnancy. IL1B initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production.Interleukin (IL)-1B is a pro-inflammatory cytokine whose expression in primary tumours has been identified as a potential biomarker for predicting breast cancer patients at increased risk for developing bone metastasis. Data SDS-PAGE Bioactivity Active Recombinant Human IL-1 beta Protein was determined by SDS-PAGE with Coomassie Blue. Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect is 1-5 ng\/mL.\u003c\/p\u003e","brand":"xfnano","offers":[{"title":"10 μg Recombinant Human IL-1 beta Protein (His-tag) 105933 \/ Store at -20°C \/ 365days","offer_id":57280516784506,"sku":"105933","price":192.19,"currency_code":"USD","in_stock":true},{"title":"100 μg Recombinant Human IL-1 beta Protein (His-tag) 105934 \/ Store at -20°C \/ 365days","offer_id":57280516817274,"sku":"105934","price":1117.19,"currency_code":"USD","in_stock":true},{"title":"500 μg Recombinant Human IL-1 beta Protein (His-tag) 105935 \/ Store at -20°C \/ 365days","offer_id":57280516850042,"sku":"105935","price":2904.69,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0907\/3606\/6938\/files\/1_27871cef-ce01-415a-9a0e-d29d5e516d17.png?v=1780024497","url":"https:\/\/chinanano.com\/es\/products\/recombinant-human-il-1-beta-protein-his-tag","provider":"xfnano","version":"1.0","type":"link"}