{"product_id":"recombinant-human-il-17a-protein-his-tag","title":"Recombinant Human IL-17A Protein (His-tag)","description":"\u003cp\u003eDESCRIPTION Gene Name Synonym IL-17A, Il17a, Ctla8, Il17 Species Human Accession Q16552 Source HEK293 cells SPECIFICATIONS Amino acid sequence Gly24-Ala155 is expressed with a 10×His tag at the C terminus Molecular Weight 15.1 kDa Purity \u0026gt;95.0% as determined by SDS-PAGE Endotoxin \u0026lt;5 EU mg-1 Formulation Lyophilized from sterile PBS, pH 7.4. Normally 5%-8% trehalose and mannitol are added as protectants before lyophilization. Reconstitution Dissolved in sterile water, it is recommended to add 0.1% HSA or BSA for long-term preservation. STORAGE Stability and Storage 12 months from date of receipt at -20°C to -70°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for almost 6 months (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage. BACKGROUND Interleukin-17A (IL17A) is also known as cytotoxic T-lymphocyte-associated antigen 8 (CTLA8),which is a proinflammatory cytokine produced by activated T cells. IL17A can regulate the activities of NF-kappaB and mitogen-activated protein kinases. Also,IL17A can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2\/COX-2), as well as enhance the production of nitric oxide (NO).Furthermore,IL17A has been found both in glycosylated and nonglycosylated forms. High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. Data SDS-PAGE Bioactivity Recombinant Human IL-17A Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 18-22 kDa. Measured by its ability to induce IL-6 secretion by NIH-3T3 mouse embryonic fibroblast cells in the presense of 20 ng\/mL TNF-α. The ED50 for this effect is ≤11.1 ng\/mL.\u003c\/p\u003e","brand":"xfnano","offers":[{"title":"10 μg IL-17A, Il17a, Ctla8, Il17 106048 \/ Store at -20°C \/ 365days","offer_id":57280523108730,"sku":"106048","price":125.0,"currency_code":"USD","in_stock":true},{"title":"100 μg IL-17A, Il17a, Ctla8, Il17 106049 \/ Store at -20°C \/ 363days","offer_id":57280523141498,"sku":"106049","price":640.63,"currency_code":"USD","in_stock":true},{"title":"500 μg IL-17A, Il17a, Ctla8, Il17 106050 \/ Store at -20°C \/ 365days","offer_id":57280523174266,"sku":"106050","price":1723.44,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0907\/3606\/6938\/files\/1_27871cef-ce01-415a-9a0e-d29d5e516d17.png?v=1780024497","url":"https:\/\/chinanano.com\/es\/products\/recombinant-human-il-17a-protein-his-tag","provider":"xfnano","version":"1.0","type":"link"}