{"product_id":"recombinant-human-il-22-protein-his-tag","title":"Recombinant Human IL-22 Protein (His-tag)","description":"\u003cp\u003eDESCRIPTION Synonym IL-22, IL22, IL-TIF, ZCYTO18 Species Human Accession Q9GZX6 Source HEK293 cells SPECIFICATIONS Amino acid sequence Ala34-Ile179 is expressed with a 10×His tag at the C terminus Molecular Weight 18.1 kDa Purity \u0026gt;95.0% as determined by SDS-PAGE Endotoxin \u0026lt;5 EU·mg-1 Formulation Lyophilized from sterile PBS, pH 7.4.Normally 5%-8% trehalose and mannitol are added as protectants before lyophilization. Reconstitution Dissolved in sterile water, it is recommended to add 0.1% HSA or BSA for long-term preservation. STORAGE Stability and Storage 12 months from date of receipt at -20°C to -70°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for almost 6 months (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage. BACKGROUND IL-22 is a relatively new cytokine that is characterized by several unique biological properties. IL-22 is a secreted cytokine produced mainly by cells of the lymphoid lineage and innate lymphoid cells. IL22 is a member of a group of cytokines called the IL-1 family of IL-1 superfamily a class of potent mediators of cellular inflammatory responses. IL22 has been shown to be an essential mediator in epithelial regeneration and wound repair. IL22 along with IL-17 is rapidly produced by splenic LTi-like cells and can be also produced by Th17 cells and likely plays a role in the coordinated response of both adaptive and innate immune systems.IL22 biological activity is initiated by binding to a cell-surface complex composed of IL-22R1 and IL-1R2 receptor chains and further regulated by interactions with a soluble binding protein, IL-22BP, which shares sequence similarity with an extracellular region of IL-22R1. IL22 also plays an important role in controlling the risk of inflammation-induced preterm birth. Data SDS-PAGE Bioactivity Active Recombinant Human IL-22 Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 22-35 kDa.\u003c\/p\u003e","brand":"xfnano","offers":[{"title":"10 μg IL-22, IL22, IL-TIF, ZCYTO18 106039 \/ Store at -20°C \/ 365days","offer_id":57280522813818,"sku":"106039","price":96.88,"currency_code":"USD","in_stock":true},{"title":"100 μg IL-22, IL22, IL-TIF, ZCYTO18 106040 \/ Store at -20°C \/ 365days","offer_id":57280522846586,"sku":"106040","price":521.88,"currency_code":"USD","in_stock":true},{"title":"500 μg IL-22, IL22, IL-TIF, ZCYTO18 106041 \/ Store at -20°C \/ 365days","offer_id":57280522879354,"sku":"106041","price":2084.38,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0907\/3606\/6938\/files\/1_27871cef-ce01-415a-9a0e-d29d5e516d17.png?v=1780024497","url":"https:\/\/chinanano.com\/es\/products\/recombinant-human-il-22-protein-his-tag","provider":"xfnano","version":"1.0","type":"link"}