{"product_id":"recombinant-human-il-5-protein-his-tag","title":"Recombinant Human IL-5 Protein (His-tag)","description":"\u003cp\u003eDESCRIPTION Gene Name Synonym IL-5, IL5, TRF, IL5, Interleukin-5 Species Human Accession P05113 Source HEK293 cells SPECIFICATIONS Amino acid sequence Asn49-Ser162 is expressed with a 10×His tag at the C terminus Molecular Weight 14.4 kDa Purity \u0026gt;95.0% as determined by SDS-PAGE Endotoxin \u0026lt;5 EU mg-1 Formulation Lyophilized from sterile PBS, pH 7.4. Normally 5%-8% trehalose and mannitol are added as protectants before lyophilization. Reconstitution Dissolved in sterile water, it is recommended to add 0.1% HSA or BSA for long-term preservation. STORAGE Stability and Storage 12 months from date of receipt at -20°C to -70°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for almost 6 months (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage. BACKGROUND IL-5 critically regulates expression of genes involved in cell survival, IgH switch recombination, maturation in B cells and genes required for growth, survival, and effector function of eosinophils. IL-5 was recognized as the major maturation and differentiation factor for eosinophils in mice and humans. IL-5 was originally defined as a T-cell-derived cytokine that triggers activated B cells for terminal differentiation into antibody-secreting plasma cells. IL-5 critically regulates expression of genes involved in proliferation, cell survival and maturation and effector functions of B cells and eosinophils. Growth in the number of circulating, airway tissue, and induced sputum eosinophils have been observed in patients with these diseases. Interleukin 5 has long been associated with several allergic diseases, including allergic rhinitis and asthma. Data SDS-PAGE Bioactivity Active Recombinant Human IL-5 Protein was determined by SDS-PAGE with Coomassie Blue. Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect is 0.1-1 ng\/mL.\u003c\/p\u003e","brand":"xfnano","offers":[{"title":"10 μg IL-5, IL5, TRF, IL5, Interleukin-5 105964 \/ Store at -20°C \/ 365days","offer_id":57280519831930,"sku":"105964","price":192.19,"currency_code":"USD","in_stock":true},{"title":"100 μg IL-5, IL5, TRF, IL5, Interleukin-5 105965 \/ Store at -20°C \/ 365days","offer_id":57280519864698,"sku":"105965","price":1232.81,"currency_code":"USD","in_stock":true},{"title":"500 μg IL-5, IL5, TRF, IL5, Interleukin-5 105966 \/ Store at -20°C \/ 365days","offer_id":57280519897466,"sku":"105966","price":3203.13,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0907\/3606\/6938\/files\/1_27871cef-ce01-415a-9a0e-d29d5e516d17.png?v=1780024497","url":"https:\/\/chinanano.com\/es\/products\/recombinant-human-il-5-protein-his-tag","provider":"xfnano","version":"1.0","type":"link"}