{"product_id":"recombinant-rat-il-1-alpha-protein-his-tag","title":"Recombinant Rat IL-1 alpha Protein (His-tag)","description":"\u003cp\u003eDESCRIPTION Synonym IL-1 alpha, Il1a, Hematopoietin-1, LEM, LAF, Pro interleukin 1 alpha, IL1F1, Preinterleukin 1 alpha Species Rat Accession P16598 Source CHO cells SPECIFICATIONS Amino acid sequence Ser115-Ser270 is expressed with a 10×His tag at the C terminus Molecular Weight 19.2 kDa Purity \u0026gt;95.0% as determined by SDS-PAGE Endotoxin \u0026lt;5 EU·mg-1 Formulation Lyophilized from sterile PBS, pH 7.4.Normally 5%-8% trehalose and mannitol are added as protectants before lyophilization. Reconstitution Dissolved in sterile water, it is recommended to add 0.1% HSA or BSA for long-term preservation. STORAGE Stability and Storage 12 months from date of receipt at -20°C to -70°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for almost 6 months (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage. BACKGROUND IL-1 alpha is a member of the interleukin 1 cytokine family. Located in the IL1 cluster, the IL1A gene is a product of IL1B gene duplication, and consequently IL-1α and IL-1β share a receptor, IL-1R1, and its downstream signaling. IL-1α has additional functions, represented by the presence of a nuclear localization signal within its pro-domain. IL-1 alpha is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. IL-1α is a substrate of noncanonical inflammatory caspases. IL-1 alpha stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. Data SDS-PAGE Bioactivity Active Recombinant Rat IL-1 alpha Protein was determined by SDS-PAGE with Coomassie Blue.\u003c\/p\u003e","brand":"xfnano","offers":[{"title":"10 μg Recombinant Rat IL-1 alpha Protein (His-tag) 105930 \/ Store at -20°C \/ 363days","offer_id":57280516653434,"sku":"105930","price":134.38,"currency_code":"USD","in_stock":true},{"title":"100 μg Recombinant Rat IL-1 alpha Protein (His-tag) 105931 \/ Store at -20°C \/ 365days","offer_id":57280516686202,"sku":"105931","price":670.31,"currency_code":"USD","in_stock":true},{"title":"500 μg Recombinant Rat IL-1 alpha Protein (His-tag) 105932 \/ Store at -20°C \/ 365days","offer_id":57280516718970,"sku":"105932","price":2084.38,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0907\/3606\/6938\/files\/1_27871cef-ce01-415a-9a0e-d29d5e516d17.png?v=1780024497","url":"https:\/\/chinanano.com\/es\/products\/recombinant-rat-il-1-alpha-protein-his-tag","provider":"xfnano","version":"1.0","type":"link"}