{"product_id":"recombinant-human-il-6-protein-his-tag","title":"Recombinant Human IL-6 Protein (His-tag)","description":"\u003cp\u003eDESCRIPTION Gene Name Synonym IL-6, IL6, Interleukin-6, BSF2, HSF, IFNB2 Species Human Accession P05231 Source HEK293 cells SPECIFICATIONS Amino acid sequence Val30-Met212 is expressed with a 10×His tag at the N terminus Molecular Weight 22.2 kDa Purity \u0026gt;95.0% as determined by SDS-PAGE Endotoxin \u0026lt;5 EU·mg-1 Formulation Lyophilized from sterile PBS, pH 7.4.Normally 5%-8% trehalose and mannitol are added as protectants before lyophilization. Reconstitution Dissolved in sterile water, it is recommended to add 0.1% HSA or BSA for long-term preservation. STORAGE Stability and Storage 12 months from date of receipt at -20°C to -70°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for almost 6 months (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage. BACKGROUND Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. IL6 is a potent inducer of the acute phase response. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as a phosphorylated and variably glycosylated molecule.IL-6 can lead to block the PI3K\/AKT pathway. It exerts actions through its heterodimeric receptor composed of IL-6R that lacks the tyrosine\/kinase domain and binds IL-6 with low affinity, and ubiquitously expressed glycoprotein 130 (gp130) that binds the IL-6. Data SDS-PAGE Bioactivity Active Recombinant Human IL-6 Protein was determined by SDS-PAGE with Coomassie Blue. Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect is 0.1-1 ng\/mL.\u003c\/p\u003e","brand":"xfnano","offers":[{"title":"10 μg IL-6, IL6, Interleukin-6, BSF2, HSF, IFNB2 105973 \/ Store at -20°C \/ 365days","offer_id":57280520159610,"sku":"105973","price":192.19,"currency_code":"USD","in_stock":true},{"title":"100 μg IL-6, IL6, Interleukin-6, BSF2, HSF, IFNB2 105974 \/ Store at -20°C \/ 365days","offer_id":57280520192378,"sku":"105974","price":859.38,"currency_code":"USD","in_stock":true},{"title":"500 μg GB300007-H-500μg 105975 \/ Store at -20°C \/ 365days","offer_id":57280520225146,"sku":"105975","price":2234.38,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0907\/3606\/6938\/files\/1_27871cef-ce01-415a-9a0e-d29d5e516d17.png?v=1780024497","url":"https:\/\/chinanano.com\/fr\/products\/recombinant-human-il-6-protein-his-tag","provider":"xfnano","version":"1.0","type":"link"}