{"product_id":"lipoic-acid-grafted-chitosan","title":"Lipoic acid grafted chitosan","description":"\u003cp\u003eProduct Name Lipoic acid grafted chitosan Product Overview Lipoic acid grafted chitosan (CS-LA) is a polysaccharide derivative obtained by covalently grafting alpha lipoic acid onto the amino group of chitosan through amide bonds. Combining the biological polysaccharide advantages of chitosan with the redox properties of the disulfide pentagonal ring of lipoic acid, CS-LA is a class of redox responsive amphiphilic biopolymers. This process introduces the unique disulfide bond (S-S) of lipoic acid on the side chain of chitosan. When the aqueous solution of chitosan modified with thioctic acid is exposed to ultraviolet light, the disulfide bond on thioctic acid absorbs light energy and breaks. The active thiol groups (- SH) formed after these breaks will quickly recombine and exchange with disulfide bonds or thiol groups on other molecules, forming new disulfide bonds. Macroscopically, this process shows that innumerable modified chitosan molecular chains are \"bridged\" through disulfide bonds to form a three-dimensional network structure, which encapsulates water molecules, thus realizing the transformation from liquid to gelled state. Technical Parameter Appearance: White sponge like solid Product Features 1) Dynamic crosslinking ability: thiooctanoic acid disulfide bond can induce ring opening polymerization by UV, and photocrosslinking can occur without photoinitiator to prepare hydrogel. 2) Stimulus responsive drug release: high GSH concentration in the tumor\/inflammatory microenvironment, disulfide bond cleavage, carrier disintegration to release loaded drugs; Combining the pH response brought by chitosan, achieving dual redox pH responsive release. Application Fields 1) Wound dressing: As an antibacterial and antioxidant hydrogel dressing, it provides an ideal microenvironment for wound healing. 2) Drug delivery carrier: Its three-dimensional network structure can serve as a delivery carrier for drugs or active factors. 3) Organizational sealant: As a photosensitive tissue sealant, it is used for intraoperative hemostasis and tissue adhesion.\u003c\/p\u003e","brand":"xfnano","offers":[{"title":"50mg White sponge like solid 111382 \/ Store at 4°C refrigerated \/ 30days","offer_id":57280591430010,"sku":"111382","price":312.5,"currency_code":"USD","in_stock":true},{"title":"100mg White sponge like solid 111383 \/ Store at 4°C refrigerated \/ 30days","offer_id":57280591462778,"sku":"111383","price":562.5,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0907\/3606\/6938\/files\/1_27871cef-ce01-415a-9a0e-d29d5e516d17.png?v=1780024497","url":"https:\/\/chinanano.com\/products\/lipoic-acid-grafted-chitosan","provider":"xfnano","version":"1.0","type":"link"}