{"product_id":"recombinant-human-il-23-protein-his-tag","title":"Recombinant Human IL-23 Protein (His-tag)","description":"\u003cp\u003eDESCRIPTION Synonym IL-23 alpha \u0026amp; IL-12 beta,CLMF,CLMF2,NKSF,NKSF2 Species Human Accession Q9NPF7\u0026amp;P29460 Source HEK293 cells SPECIFICATIONS Amino acid sequence Arg20-Pro189\u0026amp;Ile23-Ser328 is expressed with a 10×His tag at the C terminus Molecular Weight 20.1 kDa+36.1kDa Purity \u0026gt;95.0% as determined by SDS-PAGE Endotoxin \u0026lt;5 EU·mg-1 Formulation Lyophilized from sterile PBS, pH 7.4.Normally 5%-8% trehalose and mannitol are added as protectants before lyophilization. Reconstitution Dissolved in sterile water, it is recommended to add 0.1% HSA or BSA for long-term preservation. STORAGE Stability and Storage 12 months from date of receipt at -20°C to -70°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for almost 6 months (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage. BACKGROUND Interleukin 23 (IL-23) is a member of the IL-12 cytokine family and composed of two subunits, IL-12p40 and IL-23p19. heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. The main biological effects of IL-23 identified initially consist of stimulation of antigen presentation by DCs, T cell differentiation to Th17 cells, and production of interferon-γ (IFN-γ). IL-23 acts also as an end-stage effector cytokine through direct action on macrophages. Data SDS-PAGE Bioactivity Active Recombinant Human IL-23 Protein was determined by SDS-PAGE with Coomassie Blue.\u003c\/p\u003e","brand":"xfnano","offers":[{"title":"10 μg IL-23 alpha \u0026 IL-12 beta,CLMF,CLMF2,NKSF,NKSF2 106059 \/ Store at -20°C \/ 365days","offer_id":57280523862394,"sku":"106059","price":150.0,"currency_code":"USD","in_stock":true},{"title":"100 μg IL-23 alpha \u0026 IL-12 beta,CLMF,CLMF2,NKSF,NKSF2 106060 \/ Store at -20°C \/ 365days","offer_id":57280523895162,"sku":"106060","price":775.0,"currency_code":"USD","in_stock":true},{"title":"500 μg IL-23 alpha \u0026 IL-12 beta,CLMF,CLMF2,NKSF,NKSF2 106061 \/ Store at -20°C \/ 365days","offer_id":57280523927930,"sku":"106061","price":2084.38,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0907\/3606\/6938\/files\/1_27871cef-ce01-415a-9a0e-d29d5e516d17.png?v=1780024497","url":"https:\/\/chinanano.com\/products\/recombinant-human-il-23-protein-his-tag","provider":"xfnano","version":"1.0","type":"link"}