{"product_id":"recombinant-mouse-ifn-beta-protein-his-tag","title":"Recombinant Mouse IFN-beta Protein (His-tag)","description":"\u003cp\u003eDESCRIPTION Gene Name Synonym IFNB1, Interferon beta, IFN-beta, IFB, IFNB Species Mouse Accession P01575 Source HEK293 cells SPECIFICATIONS Amino acid sequence Ile22-Asn182 is expressed with a 10×His tag at the C terminus Molecular Weight 19.7 kDa Purity \u0026gt;95.0% as determined by SDS-PAGE Endotoxin \u0026lt;5 EU mg-1 Formulation Lyophilized from sterile PBS, pH 7.4.Normally 5%-8% trehalose and mannitol are added as protectants before lyophilization. Reconstitution Dissolved in sterile water, it is recommended to add 0.1% HSA or BSA for long-term preservation. STORAGE Stability and Storage 12 months from date of receipt at -20°C to -70°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for almost 6 months (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage. BACKGROUND Human type I interferons (IFNs) are a large subgroup of interferon proteins that help regulate the activity of the immune system. Interferons bind to interferon receptors. All type I IFNs bind to a specific cell surface receptor complex known as the IFN-α receptor (IFNAR) that consists of IFNAR1 and IFNAR2 chains. The IFN-β proteins are produced in large quantities by fibroblasts. They have antiviral activity that is involved mainly in innate immune response. Two types of IFN-β have been described, IFN-β1 (IFNB1) and IFN-β3 (IFNB3) (a gene designated IFN-β2 is actually IL-6). IFN-β1 is used as a treatment for multiple sclerosis as it reduces the relapse rate. Furthermore, IFN-β1 can bind to a IFNAR1-IFNAR2 heterodimeric receptor, and can also function with IFNAR1 alone and independently of Jak-STAT pathways. Data SDS-PAGE Bioactivity Recombinant Mouse IFN-beta Protein was determined by SDS-PAGE with Coomassie Blue. Determined by its ability to induce STAT1\/STAT2 activation in B16 F1 ISRE LUC reporter cells.The ED50 for this effect is 0.5-2 ng\/mL.\u003c\/p\u003e","brand":"xfnano","offers":[{"title":"10 μg IFNB1, Interferon beta, IFN-beta, IFB, IFNB 106360 \/ Store at -20°C \/ 365days","offer_id":57280529236346,"sku":"106360","price":85.94,"currency_code":"USD","in_stock":true},{"title":"100 μg IFNB1, Interferon beta, IFN-beta, IFB, IFNB 106361 \/ Store at -20°C \/ 365days","offer_id":57280529269114,"sku":"106361","price":570.31,"currency_code":"USD","in_stock":true},{"title":"500 μg IFNB1, Interferon beta, IFN-beta, IFB, IFNB 106362 \/ Store at -20°C \/ 365days","offer_id":57280529301882,"sku":"106362","price":1589.06,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0907\/3606\/6938\/files\/1_27871cef-ce01-415a-9a0e-d29d5e516d17.png?v=1780024497","url":"https:\/\/chinanano.com\/products\/recombinant-mouse-ifn-beta-protein-his-tag","provider":"xfnano","version":"1.0","type":"link"}