Product Name
Name：TTQF-SO3 NIR-II dyes
Product Overview
Optical imaging, such as fluorescence imaging and photoacoustic imaging, has the advantages of high resolution, high sensitivity and simple operation, and has been widely used in biomedical and life science fields. Compared with traditional fluorescence imaging techniques (UV-visible imaging and near-infrared region I (NIR-I, 600-900nm), near-infrared region II (NIR-II, 1000-1700nm) fluorescence imaging is lower due to the self-absorption, scattering and self-fluorescence of photons in biological tissues. It has the advantages of deep penetration and high signal-to-noise ratio (SBR). Compared with inorganic NIR-II fluorescent materials, NIR-II organic small molecule fluorescent materials show more excellent characteristics in terms of biocompatibility, structure and emission wavelength tunability. At present, the common D-A structure small molecule IR-II fluorescent contrast agent is synthesized based on the BBT receptor. However, BBT receptor has many synthetic steps and is easily decomposed in the process of column chromatography. Therefore,4, 9-bis (5-bromothiophen-2-yl) -6, 7-bis (4- (hexoxy) phenyl) -[1,2,5] thiadiazole and [3, 4-g] quinoxoline TTQ were selected as electron acceptors to synthesize a series of fluorescent molecules of IR-II.
Technical Parameter
Appearance ：Brown black powder
UV absorption peak ：~750nm
Fluorescence peak:~1100nm
Product Features
Good biocompatibility: low cytotoxicity and can be safely used for fluorescence imaging in animals.
Deep tissue penetration: The emission wavelength of IR-II fluorescent dye is longer, and it can penetrate deeper biological tissues to achieve imaging of deep tissues in the body.
High imaging resolution: Higher spatial resolution can be provided to facilitate clearer observation of biological structures and processes.
Low background interference: In this band, the fluorescence and scattered light of the biological tissue itself are weaker, improving the signal-to-noise ratio of imaging.
Application Fields
Biological imaging: IR-II fluorescent dyes can be used for deep tissue imaging, such as tumor detection, vascular imaging, neuroimaging, etc. Due to its longer emission wavelength in the NIR II region, it is able to penetrate deeper biological tissues, reducing tissue scattering and self-fluorescence interference, thus providing clearer images.
Tumor diagnosis: Tumor cells or tumor tissue can be specifically labeled to help doctors carry out early diagnosis of tumors and surgical navigation.
Drug development: For drug screening and efficacy evaluation. By labeling drugs or biomolecules, the distribution and metabolism of drugs in the body can be monitored in real time, and the efficacy and toxicity of drugs can be assessed.
Biological analysis: can be used for the detection and analysis of biological molecules, such as proteins, nucleic acids, etc.
Related Information
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