Product Name
Polyethyleneimine (PEI) modified Au nanomaterials
Product Overview
PEI-modified gold nanoparticles are modified with PEI on top of PEG-modified gold nanoparticles, and this operation makes the nanoparticles positively charged.
Technical Parameter
Concentration: 0.05mg/ml
Solvent: water
Remarks: Concentration is obtained according to the feeding ratio, actual consumption will be lower than 0.05mg/ml.
Product Features
Efficient gene delivery: PEI-modified gold nanoparticles can be used as efficient gene carriers, forming complexes with DNA through electrostatic adsorption to enhance the efficiency of gene delivery.
Excellent biocompatibility: PEI is a cationic polymer that interacts with cell membranes and promotes the binding of nanoparticles to cells, enhancing their stability and biocompatibility in organisms.
Enhanced Optical Properties: Gold nanoparticles inherently have a unique surface plasmon resonance (SPR) effect, and PEI modification can further modulate their optical properties, such as absorption and scattering characteristics, giving them potential applications in optical imaging and sensing.
Multimodal imaging capability: PEI-modified gold nanoparticles can be used in a variety of imaging techniques, such as magnetic resonance imaging (MRI), photoacoustic imaging and CT imaging, providing multimodal imaging capability.
Application Fields
Gene and siRNA delivery: PEI-modified gold nanoparticles can be used as gene and siRNA delivery carriers. It has been shown that PEI-modified gold nanoparticles can bind siRNA via covalent bonding, form complexes, and induce degradation of target mRNAs via the RNA interference (RNAi) mechanism. This approach shows high efficiency and low cytotoxicity in gene silencing.
Photothermal therapy: PEI-modified gold nanoparticles have shown excellent performance in photothermal therapy. The plasmon resonance effect on the surface of gold nanoparticles allows them to efficiently convert light energy into heat under near-infrared light irradiation, generating localised high temperatures that can kill tumour cells.PEI modification further enhances the stability and biocompatibility of the nanoparticles.
Targeted drug delivery: PEI-modified gold nanoparticles can be surface-modified with targeted ligands (e.g., folic acid, aptamers, hyaluronic acid, glutathione, peptides, and antibodies) for targeted drug delivery. This targeting significantly increases drug concentration in cancer cells and reduces toxicity to normal cells.
Radiosensitisation: PEI-modified gold nanoparticles can be used as radiosensitisers in radiotherapy. Gold nanoparticles can enhance the radiation effect of X-rays and increase the sensitivity of tumour cells to radiation, thus enhancing the effect of radiotherapy.
Related Information
Storage: Sealed, refrigerated at 4¡ãCand protected from light.
Expiry date: 6 months
Please e-mail for the detailed characterization data.
E-mail:sale@xfnano.com
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