Polyhydroxyalkanoate

Product Name Polyhydroxyalkanoate Product Overview Polyhydroxyalkanoate (PHA) microspheres are fully biodegradable polymer micro-nano spherical materials synthesized by natural microorganisms, with excellent biocompatibility, environmental friendliness and adjustable performance. This series of scientific research-grade monodisperse PHA microspheres covers a full gradient of nano and submicron particle sizes from 80 nm to 1.0 μm, with a uniform solid content of 1% and a single bottle volume of 10 ml. Prepared by precise biosynthetic modification and emulsion polymerization classification technology, the products feature full sphericity, uniform particle size, no agglomeration and excellent batch stability. Different from traditional chemically synthesized polymer microspheres, PHA is a natural polyester material produced by microbial metabolism. It can be completely degraded in natural environments and organisms without special composting conditions, with final products of carbon dioxide and water, leaving no residues and non-toxicity. Meanwhile, the mechanical properties and degradation cycle of the material can be precisely adjusted, and it supports various surface functional group modifications. It is suitable for cutting-edge fields such as biomedicine, tissue engineering, environmental degradation simulation, sustained-release drug delivery and colloid scientific research, serving as a core high-end scientific research consumable for green biomaterial research. Technical Parameter Dispersion Solvent Sterile Deionized Water Solid Content 1% Surface Modification Unmodified; All series support customized modification of various surface functional groups Surface Charge Original weak negative charge, polarity and strength adjustable by customized functional groups Color Milky white transparent uniform dispersion Characteristic Absorption Peak IR characteristic peaks: 1730cm (polyester carbonyl), 1170cm (C-O-C stretching vibration), consistent with standard PHA spectrum Excellent monodispersity, uniform particle size and high sphericity Storage Condition 2~8°C Store in a cool, dark place in a sealed container. Do not freeze and thaw, expose to high temperatures, or leave at room temperature for extended periods. Shelf Life 12个月(Under standardized unopened refrigerated storage conditions) Product Features •Pure Natural Bio-based Material with Complete Green Degradation: PHA is a polymer synthesized by natural microbial metabolism. Different from chemical synthetic materials, it can be completely degraded into carbon dioxide and water in natural environments and organisms without composting conditions, leaving no residues and pollution with extremely high biological safety, serving as the preferred substrate for green biomaterial research. •Controllable Degradation Performance for Diverse Sustained-release Scenarios: The degradation cycle can be precisely adjusted by controlling particle size, crystallinity and surface modification methods, achieving gradient sustained-release effects from several days to several months. It perfectly adapts to differentiated experimental needs such as drug sustained release, tissue repair and environmental degradation simulation, solving the pain point of uncontrollable degradation of traditional microspheres. •Full-gradient Particle Size Coverage and Rich Customization Dimensions: Standard particle sizes cover 80nm~1.0μm, and super-large particle size customization from 1μm to 200μm is supported. Combined with full-type surface group modification services, it fully matches multi-scale scientific research scenarios such as nano adsorption, micron drug loading and large-size tissue engineering scaffolds. •Ultra-high Monodispersity and Strong Experimental Repeatability: Adopting precise biological modification and fractional purification technology, the microspheres feature full sphericity, uniform particle size, no irregular particles and no agglomeration. With PDI ≤ 0.3 and excellent batch consistency, it effectively ensures accurate, stable and repeatable scientific research data. •Excellent Biocompatibility and High Medical Adaptability: The material has no cytotoxicity or irritation, and has excellent affinity with organisms, cells and tissues without causing immune rejection reactions, which can be directly applied to high-end biological research fields such as biomedicine, in-vivo experiments and tissue engineering. Strong Performance Adjustability and Outstanding Cost Performance: PHA microspheres have excellent mechanical strength, flexibility and gas barrier properties with flexibly adjustable performance. All series adopt standardized mass production and unified pricing with diversified customization services, showing significant cost performance advantages compared with similar •biodegradable microspheres. Application Fields •Biomedical Sustained-release Drug Delivery: Relying on controllable degradation and excellent biocompatibility, it can efficiently load hydrophilic and hydrophobic drugs as well as growth factors to achieve long-term and controllable sustained release, stabilize drug concentration, reduce administration times and lower toxic and side effects, suitable for the delivery research of anti-tumor drugs, anti-inflammatory drugs and biological agents. •Tissue Engineering and Regenerative Medicine: It can be used as cell carriers and tissue repair scaffold materials for research scenarios such as skin repair, bone tissue regeneration and soft tissue reconstruction. The growth and repair rhythm of tissues can be matched by adjusting particle size and degradation cycle. Environmental Biodegradation Simulation Research: As a typical environmentally friendly biodegradable material, PHA can be used in scientific experiments such as biodegradation •mechanism, microplastic alternative materials, environmental toxicology and ecological restoration in water and soil environments, serving as a core model material for environmental science. •Biological Detection and Labeling: Modified with functional groups, it can realize biomolecular coupling, specific cell labeling and immune detection analysis with low background interference and strong specificity, suitable for high-precision biosensing and in-vitro diagnostic experiments. •Green Functional Material R&D: Used for the preparation of degradable coatings, environmental protection films and biological composite functional materials to improve the biodegradability and biological adaptability of materials, adapting to the R&D and performance optimization of new environmental protection materials and disposable biomedical materials. •Basic Colloid and Interface Research: Monodisperse and stable PHA microspheres can be used in basic colloid chemistry theoretical research such as colloid assembly, Pickering emulsion stabilization, interface adsorption kinetics and particle dispersion behavior, with excellent stability and repeatability of experimental data. User Guide 1. All products of this series are scientific research-grade consumables, only for laboratory scientific research, not for medical injection or industrial end products, and shall be used according to experimental requirements. 2. The products need to be sealed and refrigerated at 2~8°C away from light. Freezing, high-temperature exposure, long-term storage at room temperature and repeated freeze-thaw are strictly prohibited. It is recommended to use up shortly after opening to prevent dispersion failure and premature degradation agglomeration of microspheres. 3. Specific particle size parameters shall be noted when ordering for large particle size customization. Customization services such as surface group modification require prior consultation with customer service to confirm the quotation, customization cycle and technical parameters. Orders without notes and consultation will be delivered with original standard specifications by default. 4. The parameters in this specification are general standard values. Minor physical deviations between batches are within the industry allowable error range and will not affect conventional scientific research experiments. 5. PHA material is biodegradable. Long-term exposure to high temperature, strong acid and alkali environments should be avoided to prevent premature degradation of microspheres and ensure experimental validity.