Poly(L-lactic acid) (PLLA)

Product Name Poly(L-lactic acid) (PLLA) Product Overview Poly(L-lactic acid) (PLLA) microspheres are a kind of polymer nano/micro microsphere materials with excellent biocompatibility and biodegradability, which are standardized mass-produced scientific research consumables. This product series covers full gradient particle sizes from 100 nm to 1.0 μm, all adopting sterile deionized water dispersion system with a uniform solid content of 1% and a single bottle volume of 10 ml. Prepared by precise nanoprecipitation and microfluidic polymerization technology, the products feature uniform particle size distribution, high sphericity, no agglomeration and excellent batch stability. As a medical-grade degradable polyester material, PLLA can be slowly degraded into carbon dioxide and water in organisms without residue, sensitization or inflammatory irritation, and has excellent carrier loading performance and structural stability. Widely applicable in biomedical research, drug sustained-release delivery, tissue engineering, medical aesthetic materials, biological detection calibration and other fields, it is a core basic consumable for biomaterial research and pre-clinical experiments. Technical Parameter Dispersion Solvent :Sterile Deionized Water Surface Modification: Unmodified (Customizable carboxyl & amino modification) Surface Charge: Weak negative charge (Zeta potential: -10~-30mV) Color:Milky white translucent uniform dispersion D:0.1 um - 400 um Solid Content 1% (Uniform and stable) Storage Condition 2~8°C Store in a cool, dark place in a sealed container. Do not freeze and thaw, expose to high temperatures, or leave at room temperature for extended periods. Shelf Life 12个月(Under standardized unopened refrigerated storage conditions) Product Features •Full Particle Size Gradient Coverage for Multi-scenario Adaptation: The product covers a complete particle size range from 100 nm to 1.0 μm. Nano-scale microspheres adapt to cell penetration and drug delivery, while micro-scale microspheres are suitable for tissue scaffolds and filling repair, fully meeting the particle size selection requirements of different scientific research and commercial experiments. •Highly Uniform Particle Size and Excellent Monodispersity: Adopting precise microfluidic synthesis technology, all specifications of microspheres have full sphericity, no irregular particles, PDI ≤ 0.3, no agglomeration or sedimentation. The parameter deviation between batches is extremely small with strong experimental repeatability. •Top-level Biosafety Performance: Made of medical-grade high-purity PLLA raw materials without heavy metals or toxic additives. It can be completely biodegraded in vivo with non-toxic and harmless metabolites, no rejection or inflammatory reaction, complying with safety standards of biomedicine and medical aesthetic materials. •Stable Dispersion System and Long Storage Period: Sterile aqueous phase dispersion system with weak negative charge surface characteristics enables long-term stable dispersion of microspheres in liquid phase. No stratification or precipitation within 12 months under standard refrigeration storage, requiring no frequent ultrasonic treatment. •Controllable Sustained-release Performance for Long-term Application: Microspheres of different particle sizes have differentiated release rates. Small particles feature fast penetration and uniform release, while large particles have longer sustained-release cycles, adapting to drug loading and tissue repair scenarios with different duration requirements. •Cost-effective and Customizable: All series specifications have unified cost and selling price with stable mass production quality and outstanding cost performance. Custom services such as surface functional modification, concentration adjustment and special particle size customization are available to meet personalized scientific research and industrial production needs. Application Fields •Basic Biomedical Research: Full-range particle size microspheres are used for cell labeling, biological tracing, cell phagocytosis experiments, biocompatibility evaluation and in vitro degradation simulation experiments, serving as core basic consumables for biomaterial laboratories in universities and research institutions. •Targeted Drug Delivery System: Small-size microspheres (100nm~500nm) are suitable for loading and encapsulating small-molecule drugs, peptides and protein active ingredients to realize targeted penetration and long-term sustained release, reduce drug toxic and side effects, and improve bioavailability. •Tissue Engineering and Regenerative Medicine: Large-size microspheres (600nm~1.0μm) can be used as scaffold fillers for tissue engineering and auxiliary materials for bone and skin repair. Relying on excellent biodegradability and bioadhesion, they promote the regeneration and repair of body tissues. Medical Aesthetic Biomaterial R&D: As degradable filling raw materials and skin anti-aging repair substrates, they are safe and non-irritating, can stimulate collagen regeneration, and are •suitable for R&D, formula optimization and pre-experimental verification of high-end medical aesthetic consumables. •Biological Detection and Instrument Calibration: Uniform-size PLLA microspheres can be used as standard calibration microspheres for the calibration of laser particle size analyzers and biological flow detectors, and also applied in trace biosensing detection experiments. •Long-acting Sustained-release Preparation Development: Relying on the full-gradient sustained-release characteristics, it adapts to the R&D of long-acting injection preparations and local sustained-release drugs, meeting the preparation development needs of different release cycles. User Guide 1. All products of this series are scientific research-grade consumables, not finished products for direct human injection, and require secondary processing according to terminal scenarios; 2. It is recommended to use up the product once opened. Avoid high temperature, strong light and freeze-thaw environments to prevent microsphere agglomeration and failure; 3. All series products support bulk procurement, functional modification and special parameter customization, with quality inspection reports and technical support provided; 4. The parameters in this specification are general standard values, and minor batch deviations are within the industry allowable error range.